Our Research

We are an international network of investigators interested in better understanding the genetic regulation of reproductive ageing.

We have a number of active projects, so please get in touch if you have relevant data and would like to contribute.


1. Elks, Perry and Sulem et al, Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics (2010) [Pubmed]

2. Stolk and Perry et al, Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics (2012) [Pubmed]

3. Perry, Corre and Esko et al, A genome-wide association study of early menopause and the combined impact of identified variants. Human Molecular Genetics (2013) [Pubmed]

4. Fernandez-Rhodes et al, Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. American Journal of Epidemiology (2013) [Pubmed]

5. Perry et al, DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. Human Molecular Genetics (2014) [Pubmed]

6. Perry, Day, Elks and Sulem et al, Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature (2014) [Pubmed]

Link to supplementary plots here

7. Lunetta, Day, Sulem et al, Rare coding variants and X-linked loci associated with age at menarche. Nature Communications (2015) [Pubmed]

8. Day, Ruth, Thompson et al, Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics (2015) [Pubmed]

9. Day, Thompson and Helgason et al, Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics (2017) [Pubmed]